However, different chemo agents affect blood cell production in different ways. Below is a list of common medications used to treat or reduce the symptoms of chemotherapy-induced neutropenia. Neutropenia is common after receiving chemotherapy. Chemotherapy drugs work by killing fast-growing cells in the body—cancer cells and healthy white blood cells. Global Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Chemotherapy Induced Neutropenia - Drugs in Development, 0 . Disease Pipeline Reviews. The mechanisms of the neutropenia are varied and the propensity to infection depends upon the adequacy of bone marrow reserve. As stated above, many drugs … The highest risk categories are antithyroid medications, macrolides, and procainamides. Neutropenia, the most serious hematologic toxicity, is associated with the risk of life-threatening infections as well as chemotherapy … Causes . The majority of chemotherapy drugs have been associated with myelosuppression. Chemotherapy works by destroying cells that grow rapidly, a … 0. Neutropenia is usually the dose-limiting side effect, so it determines the dose of chemotherapy we give. Drug class: Leukocyte Growth Factors. Neutropenia increases your risk of bacterial and fungal infections. Cytotoxic chemotherapy suppresses the hematopoietic system, impairing host protective mechanisms and limiting the doses of chemotherapy that can be tolerated. Neutropenia is a decrease in the number of white blood cells, which are the body’s main defense against infection. The most common reason that cancer patients experience neutropenia is as a side effect of chemotherapy. Drug-induced neutropenia and agranulocytosis will be reviewed here. A local search option of this data can be found here. Numerous drugs have been associated with neutropenia. Provides access to the latest drug monographs submitted to the Food and Drug Administration (FDA). It should be administered under the supervision of a qualified physician who is experienced in allogeneic hematopoietic stem cell transplantation, the use of cancer chemotherapeutic drugs and the management of patients with severe pancytopenia. You will be checked for neutropenia during treatment.   Some chemotherapy drugs are more likely to cause neutropenia than others. Drug-induced neutropenia is a potentially serious and life-threatening adverse event that may occur secondary to therapy with a variety of agents. Neutropenia. Busulfan is a potent cytotoxic drug that causes PROFOUND MYELOSUPPRESSION at the recommended dosage. FILGRASTIM, G-CSF is a granulocyte colony-stimulating factor that stimulates the growth of neutrophils, a type of white blood cell (WBC) important in the body's fight against infection. Zarxio. Cytotoxic chemotherapy can cause a predictable and dose-related decrease in neutrophil count. In fact, the development of cytotoxic chemotherapy over the last 40 years—the schedules and the doses—is based on neutropenia. JC Neutropenia is a lowering of the neutrophil count that happens in almost all patients getting chemotherapy. Please review the latest applicable package insert for additional information and possible updates. Chemotherapy attacks rapidly dividing cells, including cells in the bone marrow that become neutrophils. A list of the most common cancer drugs and their myelosuppression characteristics are listed below: Fluorouracil: all forms of myelosuppression; Oxaliplatin: neutropenia and thrombocytopenia Chemotherapy involves the use of drugs to destroy cancer cells.

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