We report a ferret model of SARS-CoV-2 infection and transmission that recapitulates aspects of human disease. An inactivated whole virus was used in ferrets, nonhuman primates and mice. Vaccine 23 (2005) 22732279 Evaluation of modied vaccinia virus Ankara based recombinant SARS vaccine in ferrets Markus Czuba,c,1, Hana Weingartlb,c,1, Stefanie Czubc, Runtao Hea,c, Jingxin Caoa,c, a National Microbiology Laboratory, Canadian Science Centre for Human and Animal Health, 1015 Arlington Street, Winnipeg, Manitoba, Canada R3E 3R2 We didnt develop a new vaccine; we took a SARS-CoV-2 purified protein. The team's vaccine uses the ferritin nanoparticles to deliver tiny, weakened fragments from the region of the SARS-CoV-2 spike protein that selectively binds to About 120 black-footed ferrets, among the most endangered mammals in North America, were injected with an experimental COVID vaccine aimed at And some attempted vaccines for SARS, a cousin of COVID-19, seemed to cause enhancement in animal testing. Vaccination of ferrets with MVA-based SARS vaccine expressing full-length S protein caused liver damage after animals were challenged with SARS-CoV . To date, there has been no exposure in the colony, but we arent going to take that risk because there are so few of them. On the other hand, vaccination did not prevent SARS-CoV infection in ferrets. This statement (in the original article) links to a 2004 study which, in response to the 2003 SARs outbreak, tested a vaccine on ferrets and found Researchers are concerned that black-footed ferrets (Mustela nigripes) may be able to contract SARS-CoV-2, the virus that causes COVID-19 in humans, since close relatives like European mink In contrast, immunized ferrets (particularly those immunized with rMVA-spike) exhibited significantly stronger inflammatory responses and focal necrosis in liver tissue after SARS-CoV challenge than control animals. There was a risk of humans transmitting it to the ferrets and back again. SARS-CoV-2-infected ferrets These findings raised concerns about the efficacy and safety of the vaccines containing or expressing full-length S protein. Before allowing use of a COVID-19 vaccine in humans, regulators should evaluate safety with a range of virus strains and in more than one animal modelWork with the SARS virus shows that worrying immune responses were seen in ferrets and monkeys, but not in mice. The screenshot of the article also claims coronavirus vaccine caused liver inflammation in test animals. We had used similar protein vaccines in ferrets At 7 weeks, the titres were 15-fold higher in ferrets vaccinated with WKV plus alum compared with animals vaccinated with Ad-S/N i.m. The hunt for a coronavirus vaccine has been horrendous for some animals. To prevent SARS-CoV-2 dissemination, understanding the in vivo characteristics of SARS-CoV-2 is a high priority. Two-thirds of captive-bred black-footed ferrets have been vaccinated for the novel coronavirus, and not a single one of the endangered mustelids is known so far to have contracted the disease. What about a SARS vaccine? Vaccine studies for SARS-CoV-1 were started and tested in animal models. Monkeys, ferrets offer needed clues in COVID-19 vaccine race.

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