Elimination: renal Half-life: 1-1.5 hours Do not exceed 2 mg/min Methylprednisolone Sodium Succinate (Solu-Medrol®) 125 mg 125 mg/mL Requires reconstitution Follow reconstitution instructions Each dose over 3-15 minutes. Mix: may be given undiluted . 1.0 IV administration routes and lines 1.1 Central: intravenous medication to be administered through a central IV line 1.1.1 A central line placed 1.1.2 Some medications cannot be administered through a peripheral IV line due to osmolarity of the drug or risk of vein irritation. Lorazepam (Ativan®) 4 mg 1 mg/mL Yes Dilute with an equal volume of D5W, NS, or SWI. Take 1 mL (3mg) and mix with 9 mL of Intravenous admixtures – preparation and infusion guidelines. It has the chemical formula: 7-chloro-5(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1, 4-benzodiazepin-2-one. While the latest survey found a decrease in some of the risky practices, many 0.05 mg/kg over 2-5 minutes. It has the chemical formula: 7-chloro-5(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2 H -1, 4-benzodiazepin-2-one. If the patient has baseline nausea, consider using 8 mg ondansetron as premedication. Dangerous IV Push Medication Practices Earlier this year, the Institute for Safe Medication Practices (ISMP) conducted a follow-up survey to three prior surveys that uncovered many dangerous intravenous (IV) push medication administration practices among clinicians. Compatible with D5W – NS Preparation / Special Considerations: Adenosine is available as a solution of 3 mg/mL (or 3000 mcg/mL), stored at room temperature. When available, domperidone 10–20 mg orally or by suppository may be used. ATIVAN (lorazepam) Injection Rx only DESCRIPTION Lorazepam, a benzodiazepine with antianxiety, sedative, and anticonvulsant effects, is intended for the intramuscular or intravenous routes of administration. A patient must have a central line available to receive these Guidelines for Use of LORazepam (Ativan ®) Recommended Neonatal Dose, Route, and Interval IV/PO Dosing: 0.05-0.1mg/kg/dose, repeat doses based on clinical response Give slow IV push over 5 minutes Indications Status epilepticus Sedation Possible Adverse … It has the chemical formula: 7-chloro-5(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1, 4-benzodiazepin-2-one. If needed Adenosine could be diluted with NS. to strive to minimize nausea) 4 mg IV every 8 hours, 30 minutes before each DHE infusion. Ativan (lorazepam) 0.1mg/kg Max dose 4mg Dilute 1:1 with NS Max rate 2mg/minute Stable in D5W, LR, NS Monitor IV site avoid extravasation Atropine [symptomatic bradycardia] 0.5mg q3-5 minutes Max 3mg Undiluted IVP over 30-60 seconds Stable in NS Avoid use in hypothermic bradycardia Benadryl (diphenhydramine) Rapid IV push (1 to 2 seconds) Infuse as close to IV site as possible. Mechanism: inhibits reabsorption of sodium and chloride in the ascending loop of Henle and proximal renal tubule. lorazepam (Ativan): (IV Push): What are the specific dilution instructions for administering this drug by IV push route? Lorazepam, a benzodiazepine with antianxiety, sedative, and anticonvulsant effects, is intended for the intramuscular or intravenous routes of administration. Day 1: First dose: 0.5 mg in 100 mL of normal saline over 1 hour Continuous IV infusion: 0.9-1 mg/hour . dilution, reconstitution, or the safe rate of administration of IV push medications Risks Associated with Drug Labeling, Packaging, and Nomenclature • IV medications that are prepared in empty sterile syringes, but left unlabeled Each monograph contains stability data, administration guidelines, and methods of preparation. Dilute immediately before use with an equal amount of sterile water for injection, D5W, or 0.9% NaCl for injection. May administer at faster rates in emergency Lorazepam, a benzodiazepine with antianxiety, sedative, and anticonvulsant effects, is intended for the intramuscular or intravenous routes of administration. Dose: 0.5-1 mg/ dose IV push over 1-2 mins; maximum 10 mg/day . Flush IV with NS immediately. This reference contains standard dilutions including IV admixture drug concentration, infusion volumes, and infusion rates.

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